fannish argosies

RSS

kissmyasajj:

fuckyeahwarriorwomen:

duckindolans:

daughterofmulan:

theblindninja:

The Pirates Official Posters

What is this glorious looking glory.

WHAT IS THIS

Pirates (2014 film)

Set in the early Joseon Dynasty, a group led by a female pirate and another group led by a male bandit are on a mission to hunt down a whale that swallowed the royal seal bestowed on Joseon from China.

Yes!

Schizophrenia not a single disease but multiple genetically distinct disorders

neurosciencestuff:

New research shows that schizophrenia isn’t a single disease but a group of eight genetically distinct disorders, each with its own set of symptoms. The finding could be a first step toward improved diagnosis and treatment for the debilitating psychiatric illness.

image

The research at Washington University School of Medicine in St. Louis is reported online Sept. 15 in The American Journal of Psychiatry.

About 80 percent of the risk for schizophrenia is known to be inherited, but scientists have struggled to identify specific genes for the condition. Now, in a novel approach analyzing genetic influences on more than 4,000 people with schizophrenia, the research team has identified distinct gene clusters that contribute to eight different classes of schizophrenia.

“Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.”

Cloninger, the Wallace Renard Professor of Psychiatry and Genetics, and his colleagues matched precise DNA variations in people with and without schizophrenia to symptoms in individual patients. In all, the researchers analyzed nearly 700,000 sites within the genome where a single unit of DNA is changed, often referred to as a single nucleotide polymorphism (SNP). They looked at SNPs in 4,200 people with schizophrenia and 3,800 healthy controls, learning how individual genetic variations interacted with each other to produce the illness.

In some patients with hallucinations or delusions, for example, the researchers matched distinct genetic features to patients’ symptoms, demonstrating that specific genetic variations interacted to create a 95 percent certainty of schizophrenia. In another group, they found that disorganized speech and behavior were specifically associated with a set of DNA variations that carried a 100 percent risk of schizophrenia.

“What we’ve done here, after a decade of frustration in the field of psychiatric genetics, is identify the way genes interact with each other, how the ‘orchestra’ is either harmonious and leads to health, or disorganized in ways that lead to distinct classes of schizophrenia,” Cloninger said. 

Although individual genes have only weak and inconsistent associations with schizophrenia, groups of interacting gene clusters create an extremely high and consistent risk of illness, on the order of 70 to 100 percent. That makes it almost impossible for people with those genetic variations to avoid the condition. In all, the researchers identified 42 clusters of genetic variations that dramatically increased the risk of schizophrenia.

“In the past, scientists had been looking for associations between individual genes and schizophrenia,” explained Dragan Svrakic, PhD, MD, a co-investigator and a professor of psychiatry at Washington University. “When one study would identify an association, no one else could replicate it. What was missing was the idea that these genes don’t act independently. They work in concert to disrupt the brain’s structure and function, and that results in the illness.”

Svrakic said it was only when the research team was able to organize the genetic variations and the patients’ symptoms into groups that they could see that particular clusters of DNA variations acted together to cause specific types of symptoms.

Then they divided patients according to the type and severity of their symptoms, such as different types of hallucinations or delusions, and other symptoms, such as lack of initiative, problems organizing thoughts or a lack of connection between emotions and thoughts. The results indicated that those symptom profiles describe eight qualitatively distinct disorders based on underlying genetic conditions.

The investigators also replicated their findings in two additional DNA databases of people with schizophrenia, an indicator that identifying the gene variations that are working together is a valid avenue to explore for improving diagnosis and treatment.

By identifying groups of genetic variations and matching them to symptoms in individual patients, it soon may be possible to target treatments to specific pathways that cause problems, according to co-investigator Igor Zwir, PhD, research associate in psychiatry at Washington University and associate professor in the Department of Computer Science and Artificial Intelligence at the University of Granada, Spain.

And Cloninger added it may be possible to use the same approach to better understand how genes work together to cause other common but complex disorders.

“People have been looking at genes to get a better handle on heart disease, hypertension and diabetes, and it’s been a real disappointment,” he said. “Most of the variability in the severity of disease has not been explained, but we were able to find that different sets of genetic variations were leading to distinct clinical syndromes. So I think this really could change the way people approach understanding the causes of complex diseases.”

(Source: news.wustl.edu)

officialjeffgoldblum:

emasculate:

teenbitch:

WHAT

i honestly love this more than anything in the world

i thought this was a joke but i googled it and it’s real

officialjeffgoldblum:

emasculate:

teenbitch:

WHAT

i honestly love this more than anything in the world

i thought this was a joke but i googled it and it’s real

trinketsabernathy:

Marvel’s Agents of S.H.I.E.L.D + Maria Hill’s beauteous not amused face

meglyman:

What are the Avengers without Nick Fury? Roughly 56 arms of heroic chaos, that’s what.
Etsy link

meglyman:

What are the Avengers without Nick Fury? Roughly 56 arms of heroic chaos, that’s what.

Etsy link

Items People Tried To Sneak Through Customs

alicehopewalker:

sixpenceee:

A wooden door stuffed with cocaine

image

Frogs in a film canister

image

Cocaine disguised as candy

image

Cats filled with opium

image

Snake in a clay pot

image

A gecko in a false book

image

A metric ton of marijuana as a donkey

image

SOURCE & MORE IMAGES

A METRIC TON OF WEED

currentsinbiology:

Fine Whitework - Apprentice, Lucy Reed

currentsinbiology:

Fine Whitework - Apprentice, Lucy Reed

romeitoiumono:

…don’t ever forget that!

And don’t say "I’ll never be good". You can become better! and one day you’ll wake up and you’ll find out how good you actually became.

「Neil deGrasse Tyson」

asylum-art:

10 Magical Pebble Paths That Flow Like Rivers

The garden or back-yard is one of the best places in a home for the home-owner to express their creative side. Why surround all those beautiful plants with an ugly path when you can create a creative stone garden path that looks like a work of art? We collected this list to show you what a well-done pebble garden path can look like.

River stones and pebbles worked really well for the projects in these pictures, but just about any stone can work as long as you can think of a cool design with it and turn it into a stable path.

  1. Judy White
  2. unknown
  3.  Claire Ashman
  4. Francesca Gallo
  5.  sarako
  6. pebbleandcomosaics.com
  7. Sarah Garner
  8. lorifeger.hubpages.com
  9. Chuck Domitrovich
  10. Jeffrey Bale

deputychairman:

torstai-kilpikonna:

I learned two things from my father. One: Timing. Mostly when to duck. And two: You never hit a kid. ‘Cause it doesn’t teach him anything.

Favourite Ray Vecchio moments: Episode 1.11 (Gift of the Wheelman)

I just have so many FEELINGS about this scene. Starting with how you can practically see Fraser putting his own father’s shortcomings into perspective: yes, Bob Fraser pretty much Failed at parenting, but at least he taught his kid things like “never follow a man off a cliff” rather than when to duck. There’s a difference. 

And moving on to how much this is the buddy cop show equivalent of pillow talk. It’s dark, the two of them are alone, and there’s Fraser with his head tipped back, body language all relaxed like you NEVER see, and his fingers almost in his mouth? That makes me have Feelings too.

currentsinbiology:

The Biologist, of course, misses on purpose!

currentsinbiology:

The Biologist, of course, misses on purpose!

I want to do a rom-com with Melissa McCarthy. I even told her that at an awards show, and she said ‘Yes, Let’s do it!’

-

Idris Elba, on his dream role, to US Weekly (via camewiththeframe)

Where she’s a high powered executive neat freak and he’s sort of slovenly. I want this like air.

(via barefootdramaturg)

oh my god, shut up and take my money

(via mizkit)

nightlyknitter:

woolymatt:

aduckyforchristmas:

“What are you doing today?”

image

“BUT IT’S CHRISTMAS EVE!”

Okay then…

image

story of my life.

My ideal Christmas

(Source: serafinacastaway)

nbchannibal:

LET THE WINE FLOW! GILLIAN ANDERSON IS NOW A SERIES REGULAR!

(Source: teflonly)